A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes

Purpose: In the current study, we aimed to look into macroscopic and microscopic dose enhancement effect of metallic nanoparticles in interstitial brachytherapy gastric adenocarcinoma by Iodine-125 source using a nano-lattice model MCNPX (2.7) MCNP6.1 codes. Materials methods: Based on simulation containing radiation tumor tissue with cellular compartments loaded 7 mg/g spherical nanoparticles, levels energy deposition secondary electrons was estimated. Results: The results show that values DEF are higher than decrease increasing distance from surface source. Accordingly, it could be noted gold have highest radiosensitization among other related value is close resultant for bismuth nanoparticles. Moreover, revealed remarkable discrepancy between electron spectra calculated codes, which justified difference cut-off transport algorithms two Conclusions: According both outputs, concluded presence increases physical effectiveness I-125 This study aims provide recommendations future preclinical studies. Actually, presented herein give view potential different considered design analytical experimental studies regions various radiotherapy modalities heavy nanomaterials.